NIAMS Multidisciplinary Clin Res Ctr: Rheumatic Diseases

拟议的多学科临床研究中心（MCRC）是一个自然的产物， 流行病学_教育/卫生服务研究组成部分的多功能关节炎和 北方大学瑟斯顿关节炎研究中心肌肉骨骼疾病中心 查佩尔山的卡罗莱纳。该中心拥有一大批经验丰富的研究人员和管理人员， 与医学院、公共卫生学院、牙科学院、药学院和护理学院以及 内科、儿科、骨科、家庭医学、社会医学、放射科， 流行病学、健康行为与健康教育、卫生政策与管理、生物统计学。 MCRC的目标是：1）在各种领域进行严格的跨学科临床研究， 肌肉骨骼疾病; 2）指导方法核心，以支持方法，分析， 三）促进发展新的 研究思路和资助关节炎和肌肉骨骼疾病的新研究项目。为了 为了实现这些目标，拟议的MCRC将包括一个方法学核心，三个临床项目和一个 行政核心。方法论核心将构成中心的基础，并将服务于 以下职能：1）方法学和生物统计学咨询和审查; 2）测量 开发; 3）数据支持服务，包括数据收集，数据管理和分析; 4）数据和 安全监控; 5）教学。这三个拟议的项目是：1）金属在骨关节炎中的作用 在多种族的农村人口中（主要研究者：Joanne Jordan博士）; 2）个人和 关节炎结局的社区社会决定因素（主要研究者：Leigh卡拉汉博士）;以及 3)血管炎患者的社会支持、控制感和心理调适 合作伙伴（主要研究者：Robert DeVellis博士）。这些项目包括流行病学和 不同患者人群的生物行为方法：北卡罗来纳州特定农村社区的骨关节炎 卡罗莱纳;横跨北卡罗来纳州州的社区家庭实践中的关节炎;以及小血管 在东南部练习时得了血管炎每个项目都是创新的，解决了 很少或从未在关节炎和风湿性疾病的背景下进行检查。该地区的共同主题 对每个项目的探究是对个人领域之外的影响和问题的探究。上 在项目中，环境暴露是个人外部的力量。在第二个项目中，重点是 一个人所居住的社区的社会经济地位对关节炎结果的影响。最后 个人与配偶的互动是第三个项目的调查重点。行政 核心将为中心提供财务和科学监督和指导，并将由一个 主任、副主任、执行委员会和支助人员。

The proposed Multidisciplinary Clinical Research Center (MCRC) is a natural outgrowth of the Epidemiology_ducation/Health Services Research Component of the Multipurpose Arthritis and Musculoskeletal Diseases Center of the Thurston Arthritis Research Center at the University of North Carolina at Chapel Hill. The center has a large cadre of experienced researchers and administrators with direct linkages to the Schools of Medicine, Public Health, Dentistry, Pharmacy, and Nursing and to the Departments of Medicine, Pediatrics, Orthopaedics, Family Medicine, Social Medicine, Radiology, Epidemiology, Health Behavior and Health Education, Health Policy and Administration, and Biostatistics. The objectives of the MCRC are 1) to conduct rigorous interdisciplinary clinical research in a variety of musculoskeletal conditions; 2) to direct a Methodology Core to support the methodological, analytical, and statistical needs of the funded projects and other future projects; and 3) to foster the development of new research ideas and the funding of new research projects in arthritis and musculoskeletal diseases. In order to achieve these goals, the proposed MCRC will consist of a Methodology Core, three clinical projects, and an Administrative Core. The Methodology Core will form the foundation of the Center and will serve the following functions: 1) methodological and biostatistical consultation and review; 2) measurement development; 3) data support services including data collection, data management, and analysis; 4) data and safety monitoring; and 5) teaching. The three proposed projects are 1) The role of metals in osteoarthritis in a multi-ethnic, rural population (Principal Investigator: Dr. Joanne Jordan); 2) Individual and Community Social Determinants of Arthritis Outcomes (Principal Investigator: Dr. Leigh Callahan); and 3) Social support, perceived control, and psychological adjustment in vaseulitis patients and their partners (Principal Investigator: Dr. Robert DeVellis). The projects include epidemiologic and biobehavioral approaches to distinct patient populations: osteoarthritis in a specific rural community in North Carolina; arthritis in community family practices spanning the state of North Carolina; and small vessel vasculitis from practices across the Southeast. Each project is innovative and addresses issues which have rarely or never been examined in the context of arthritis and rheumatic diseases. A common theme to the area of inquiry of each project is that of influences and issues outside the realm of the individual. In the first project, environmental exposures are the forces outside the individual. In the second project, the focus is the impact of the socioeconomic status of the community in which one lives upon arthritis outcomes. Finally, the interaction of the individual and his/her spouse is the focus of inquiry of the third project. An Administrative Core will provide financial and scientific oversight and direction to the Center and will be composed of a Director, an Associate Director, an Executive Committee, and support staff.