Biological Informatics Core

生物信息核心(BIC)的总体目的是提供生物信息和生物科技 对项目1至3的支持。核心将利用其在 马里兰大学医学院，基因组科学研究所(IGS)，执行衣原体 沙眼衣原体和沙眼衣原体基因组分析，如基因组序列组装， Novo注释/重新定位和基因组序列比较分析，2)元基因组分析 元翻译数据，如转录组合、功能注释、比较功能 转录本的分析、系统基因组学分析和社区代谢途径的重建；3) 基于模型的社区组成与每个社区中收集的元数据相关的统计分析 项目；4)开发基于网络的资源，用于分发、访问、浏览、查询和分析 三个项目各产生的数据1-3。生物信息学核心将近距离工作 与爱达荷州大学的Abdo博士合作，他将负责统计分析， 而怀特博士将领导IGS的剩余工作。为该项目组建的团队包括 有经验的生物信息学家和科学学家，他们在基因组改革的开始，而在 20世纪90年代的基因组研究所。他们的高水平专业知识和服务于 开放访问数据和软件的研究科学界将是确保数据 生物信息核心将支持的项目的结果将对 衣原体和性传播感染临床和研究社区。

The overall purpose of the Biological Informafics Core (BIC) is to provide bidnformafics and biostafisfical support to projects 1 to 3. The core will leverage its major computafional and human infrastructure at the University of Maryland School of Medicine, Institute for Genome Sciences (IGS), to perform 1) Chlamydia trachomatis and Chlamydia caviae genomic based analyses, such as genome sequence assemblies, de novo annotation/remapping and genome sequences comparative analyses, 2) metagenomic analyses of metatranscriptomic data such as transcripts assemblies, functional annotafion, comparative funcfional analyses, phylogenomic analyses of the transcripts, and community metabolic pathways reconstrucfion; 3) model-based statistical analyses of community composition in relation to the metadata collected in each project; 4) develop a web-based resource for the distribution, access, browsing, querying and analysis of the data generated by each of the three projects 1-3. The Biological Informatics Core will work in close cdlaborafion with Dr. Abdo, at the University of Idaho who will be responsible for the stafisfical analysis, while Dr. White will lead the remaining acfivifies at IGS. The team assembled for this project comprises of experienced bioinformaficists and scienfists, who were at the onset of the genomic revdufion while at the Institute for Genomic Research in the 1990s. Their high level of expertise and commitment to serve the research scientific community with open-access to data and software will be key in making sure that the data and findings of the projects the Biological Informafics Core will support will have maximum impact on the chlamydial and STI clinical and research community.