Cellular Immunity to Category A-C Viruses in Humans

拟议中的麻省大学人类免疫学和生物防御转化研究中心是一个 全面的、跨部门的合作，作为其总的科学主题， T淋巴细胞应答在A-C类病毒病原体免疫发病机制和保护中的作用 该中心包括高级和初级研究人员，他们具有重要的人类学专业知识。 免疫学和生物防御病原体的研究，包括转化为临床研究， 围绕以下组成部分组织： - 项目1（痘病毒）将定义牛痘病毒的免疫显性人类T细胞表位作为 疫苗的有效性和先进的知识对改进天花疫苗的发展。 - 项目2（汉坦病毒）将定义与汉坦病毒免疫发病机制相关的人类免疫应答。 肾综合征出血热 - 项目3（黄病毒）将定义保护性和免疫病理学交叉反应性人类T细胞 对连续病毒感染的反应。 - 技术开发部门（TDC）将开发新型固相阵列和蛋白质组学 用于T细胞表位鉴定、病毒特异性T细胞的检测和计数的技术 细胞，以及鉴定保护性或病理性T细胞应答的生物标志物。 - 核心设施将提供流式细胞术，MHC I类生产，MHC II类生产和程序 行政服务，供研究项目及贸发局使用。 - 试点项目部分将支持试点资助有前途的新的研究概念， UMS教师。教育部分将支持非中心研究者的短期培训。 拟议的中心将解决与这些生物防御病原体相关的重要NIAID研究优先事项 以及年轻调查员的职业发展。该中心将促进协同互动 通过定期内部和外部审查进行评估，这将大大 提高整体科研生产力。

The proposed UMass Center for Translational Research on Human Immunology and Biodefense is a comprehensive, interdepartmental collaboration to address, as its overall scientific theme, the role of human T lymphocyte responses in the immunopathogenesis of and protection from category A-C viral pathogens. The Center encompasses senior and junior investigators with significant prior expertise in human immunology and research on biodefense pathogens, including translation to clinical studies, and is organized around the following components: - Project 1 (Poxviruses) will define immunodominant human T cell epitopes of vaccinia virus as markers of vaccine efficacy and advance knowledge toward the development of improved smallpox vaccines. - Project 2 (Hantaviruses) will define human immune responses associated with immunopathogenesis of hemorrhagic fever with renal syndrome. - Project 3 (Flaviviruses) will define protective and immunopathological cross-reactive human T cell responses to sequential virus infections. - The Technical Development Component (TDC) will develop novel solid-phase array and proteomics technologies for application in T cell epitope identification, detection and enumeration of virus-specific T cells, and identification of biomarkers of protective or pathological T cell responses. - Core facilities will provide flow cytometry, MHC class I production, MHC class II production, and program administration services for use by the research projects and TDC. - A Pilot Projects component will support pilot funding of promising novel research concepts proposed by UMMS faculty. An Education component will support short-term training of non-Center investigators. The proposed Center will address important NIAID research priorities related to these biodefense pathogens as well as career development for young investigators. The Center will facilitate synergistic interactions between the various investigators, to be assessed by periodic internal and external review, that will greatly enhance the overall research productivity.