Methods for increasing the accuracy and efficiency of population based studies of the association between genes and disease

与居住在世界不同地区的人相比，居住在一起的人在基因上往往更相似。其中一个原因是他们分享了更多的基因祖先。即使在国家内部，基因变异的模式也可能存在非常细微的差异。考虑到这些细微的差异对于研究疾病的遗传基础可能很重要。我们将开发新的统计方法来控制疾病研究中的这些遗传差异。

Individuals who live near each other tend to be more similar genetically than individuals who live in different parts of the world. One reason is that they share more of their genetic ancestry. There can be very subtle differences in patterns of genetic variation even within countries. Accounting for these subtle differences can be important for studies of the genetic basis of diseases. We will develop novel statistical methods to control for these genetic differences in disease studies.