Aspergillus Genome Database

描述(由申请人提供)：该项目的目标是开发一个数据库，基于用于酵母菌和念珠菌基因组数据库的软件和模式，用于曲霉属，其中将有从与特定基因相关的文献中精选的数据。在文献管理中，我们将记录基因名称和别名、基因本体论注释和突变表型，并为探索基因组及其注释提供工具和界面。此外，我们将进一步开发和完善一个强大的、最先进的基因组注释管道，并使用它对每个曲霉进行初级基因组注释。这条流水线将利用曲霉之间的比较基因组数据，并将定期重新运行，无论是当新数据曝光时(例如额外的基因组)，或者当改进的算法被纳入流水线时。因此，我们将为曲霉研究社区提供高质量的基于文献的整理，以及对每个基因组的最好的可能的初级注释。通过这种方式，就像在其他生物体研究社区中所做的那样，我们将通过使研究人员能够轻松地获取相关注释信息来帮助加快对曲霉的研究。这一点尤其重要，因为曲霉既含有条件致病菌烟曲霉，也含有模式遗传有机体A.nidulans，对这些有机体的研究将对人类健康产生积极影响。公共卫生相关性：烟曲霉是一种在世界各地发现的机会性病原体，主要感染中性粒细胞减少的动物宿主；它是人类侵袭性霉菌感染的最常见原因，也是显著的发病率和死亡率的原因。在没有抗真菌药物治疗的情况下，由烟曲霉菌引起的侵袭性疾病的死亡率很高；即使进行治疗，死亡率仍保持在至少50%。这个项目的成功完成，提供了一个经过精选的曲霉数据库，可能会加速曲霉的研究，这样做将有助于对抗烟曲霉菌感染，从而对人类健康产生重大积极影响。

DESCRIPTION (provided by applicant): The goal of this project is to develop a database, based on the software and schema used for the Saccharomyces and Candida Genome Databases, for the Aspergilli, wherein there will be data curated from the literature connected to specific genes. In curating the literature, we will record gene names and aliases, Gene Ontology annotations, and mutant phenotypes, as well as provide tools and interfaces for exploring the genome and its annotations. In addition, we will further develop and refine a robust, state-of-the-art genome annotation pipeline, and use this to perform primary genome annotation on each of the Aspergilli. This pipeline will take advantage of comparative genomic data between the Aspergilli, and will be re-run periodically, either when new data come to light (such as additional genomes), or when improved algorithms are incorporated into the pipeline. Thus, we will provide to the Aspergillus research community high quality literature based curation, coupled with the best possible primary annotation of each of the genomes. In this way, as has been done in other organism research communities, we will help to accelerate research into the Aspergilli, by enabling researchers to easily access relevant annotation information. This is particularly important, as the Aspergilli contain both the opportunistic pathogen, A. fumigaus, as well as the model genetic organism, A. nidulans, and enabling research into these organism will have a positive impact on human health. PUBLIC HEALTH RELEVANCE: Aspergillus fumigatus is an opportunistic pathogen found throughout the world and primarily infects neutropenic animal hosts; it is the most common cause of invasive mold infections in humans and the cause of significant morbidity and mortality. Invasive disease caused by A. fumigatus has a high mortality rate in the absence of antifungal drug therapy; even with treatment, mortality still remains at least 50%. Successful completion of this project, to provide a curated Aspergillus database, will likely accelerate Aspergillus research, and in doing so will aid in the fight against A. fumigatus infections, and thus significantly positively impact human health.