Problem Solving in Transplant Patients and Caregivers

本研究旨在测试问题解决教育干预在接受异基因造血干细胞移植(HSCT)的患者和家庭照料者中的潜在应用。研究表明，解决问题的增加可以减少痛苦，并可能改善症状痛苦和与健康相关的生活质量。准备好的家庭护理干预，也被称为COP，已经显示出对癌症患者及其家人的好处，但目前的应用存在局限性。只有一项研究报告了这种干预措施在急性护理环境中的应用，还没有对接受造血干细胞移植的患者进行研究。 受试者一旦同意参加美国国立卫生研究院临床中心的异基因造血干细胞移植，就应遵守该方案。到目前为止，已经对19名研究参与者及其家庭照顾者进行了潜在参与的筛查。五对夫妇(患者和照顾者)符合条件并同意参加。3名学生已完成学习，2名学生正在接受教育干预。不符合资格的原因包括：非英语阅读和看护人在场不一致。 这项研究的结果将指导未来的研究，与接受异基因造血干细胞移植的双胞胎患者的常规护理小组教育相比，检验与问题解决教育干预相关的预测因素和结果。

This study is designed to test the potential application of a problem-solving education intervention for patients and family caregivers experiencing allogeneic hematopoietic stem cell transplantation (HSCT). An increase in problem-solving has been shown to decrease distress and may improve symptom distress and health related QOL. The Prepared Family Caregiving intervention, also known as COPE, has demonstrated benefit in cancer patients and their families, however there are limitations to its current application. Only one study has reported the application of this intervention in the acute care setting and no study has been done with patients undergoing HSCT. Subjects are accrued to this protocol once they have agreed to participate in an allogeneic HSCT at the Clinical Center, NIH. To date, 19 research participants and their family caregivers have been screened for potential participation. Five dyads (patient and caregiver) were eligible and agreed to be enrolled. Three dyads have completed study participation and 2 are receiving their education intervention. Reasons for in-eligibility include: non-English reading and inconsistent caregiver presence. The results to this study will guide future research examining predictors and outcomes associated with problem solving education intervention as compared to usual care group education in dyads receiving allogeneic HSCT.