Carbohydrate-Dependent Adhesion in Normal&Tumor Cells

这个项目研究了碳水化合物的结构、生物合成和在细胞中的作用。 互动。建议的项目得到了我们强有力的合作研究的支持。 在上一个供资期间开展的活动。该计划项目是一个持续密切的合作 在研究人员中，他们的专长从碳水化合物合成化学， 碳水化合物生物合成，免疫学，细胞和分子生物学。在未来的几年里， 我们将通过结合活体显微镜观察来增强研究能力 体内细胞的迁移和相互作用。 这项工作主要围绕着硫化、岩藻糖化的糖偶联物在淋巴细胞运输、肿瘤 进展和骨髓生成。这项工作包括碳水化合物介导的信号的作用 通过研究岩藻糖在Notch信号转导中的作用，这是该领域的一个新的研究方向。 这项工作还确定了碳水化合物依赖的肿瘤转移的作用，通过识别 新型碳水化合物识别分子及其在肿瘤靶向研究中的应用 硫酸肝素在肿瘤血管生成中的作用。 这些研究将为碳水化合物在慢性粒细胞生成中的作用提供新的信息。 炎症、肿瘤进展和碳水化合物依赖的信号转导。这个 从这些研究中获得的知识可能有助于设计改进的治疗干预措施 对抗恶性肿瘤和其他疾病。

This program project examines the structure, biosynthesis, and roles of carbohydrates in cell-cell interaction. The proposed projects were borne-out from our strong collaborative research activities in the previous funding period. This program project is a continued close collaboration among investigators whose expertise ranges from carbohydrate synthetic chemistry, carbohydrate biosynthesis, immunology, to cellular and molecular biology. In the coming years, we wilt add strength in research capability by incorporating intravital microscopy to observe migrating and interacting cells in vivo. The work centers around sulfated, fucosylated glycoconjugates in lymphocyte trafficking, tumor progression, and myelopoiesis. The work includes the role of carbohydrate-mediated signal transduction, a novel aspect in the field, through studies on the role of fucose in Notch signaling. The work also determines the role of carbohydrate-dependent tumor metastasis by identifying novel carbohydrate recognition molecules and their use for tumor targeting, and determining the roles of heparan sulfate in tumor angiogenesis. These studies will provide new information on the roles of carbohydrates in myelopoiesis, chronic inflammation, tumor progression, and carbohydrate-dependent signal transduction. The knowledge gained from these studies may help in the design of improved therapeutic intervention against malignancies and other diseases.