Continued development of WHONET for surveillance of infections & drug resistance

项目概述/摘要：传染病、新发现的病原体和多重耐药微生物（如MRSA、VRE和MDR-TB）的持续出现，是全球优先考虑的问题，威胁着全世界患者的福祉，消耗着有限的卫生保健资源。然而，遏制公共卫生战略的有效性和政府追踪和减少感染任务的可行性受到行动工具和信息基础不足的限制。在世界各地的微生物实验室中，现有但分散的测试结果存储库被锁定在纸质日志和不兼容的计算机系统中，这构成了一个复杂而丰富的资源，但在很大程度上尚未开发，可用于跟踪微生物种群的出现、传播和进化传播。我们在波士顿世卫组织抗微生物药物耐药性监测合作中心的团队在开发追踪抗微生物药物耐药性新趋势的软件方面拥有40年的经验，与世界卫生组织的国家、区域和世界总部协调，一直是动员和规范这一信息资源以支持协调的科学调查和公共卫生行动的领导者。我们努力的一个基石是开发和传播WHONET软件，这是一种灵活、复杂、用户友好的微生物检测结果管理和分析工具。在90多个国家，研究人员、微生物学家、临床医生、公共卫生流行病学家和国家监测协调员利用世卫网络，主要在地方和国家一级管理来自1200多个临床、公共卫生、兽医、食品和学术实验室的结果，用于基础科学、临床和业务研究；公共卫生政策；临床决策支持;以及实验室能力建设。本提案的目标是：a)为现有的世卫网络软件提供持续支持，同时整合最新的适当信息技术、本体和信息学标准；(b)在疫情检测、数据可视化、自动化、通知和信息流等领域对世卫网络分析功能进行重大改进；c)提高现有软件用户对世界卫生组织网络的有效利用，将其应用扩展到新的技术和地理领域，并促进合作研究网络中的数据共享。这些发展将加强我们努力的科学和公共卫生影响，并促进在制定和评估感染和抗微生物药物耐药性控制干预措施方面进行合作研究所需的战略基础设施。项目说明：传染病、新发现的病原体和耐多药微生物的持续出现是一个全球优先事项，威胁着全世界患者的福利，并消耗有限的医疗保健资源。在90多个国家使用的世卫组织网络软件为研究人员和公共卫生当局提供了工具，用于跟踪感染和耐药性的新趋势，并制定和评估遏制和控制的干预措施。该项目的目标是扩大世卫组织网络在数据共享、疫情检测、警报通知以及公共卫生和科学监测网络合作研究等领域的应用。

DESCRIPTION (provided by applicant): Development of WHONET for Surveillance of Infections and Drug Resistance John Stelling, MD, MPH Project Summary/Abstract The continued emergence of infectious diseases, newly identified pathogens, and multi-drug resistant microorganisms, such as MRSA, VRE, and MDR-TB, is a global priority which threatens patient welfare worldwide and drains limited healthcare resources. Yet the effectiveness of public health strategies for containment and the feasibility of government mandates to track and decrease infections is limited by inadequate tools and information bases for action. The existing, yet dispersed, repositories of test results locked into paper logbooks and incompatible computer systems in microbiology laboratories worldwide constitutes a complexly rich, yet largely untapped resource for tracking the emergence, transmission, and evolutionary spread of microbial populations. With four decades of experience in the development of software to track emerging trends in antimicrobial resistance, our team at the WHO Collaborating Centre for Surveillance of Antimicrobial Resistance, Boston, in coordination with the national, regional, and world headquarters of the World Health Organization, has been a leader in mobilizing and normalizing this information resource to support coordinated scientific investigations and public health action. A cornerstone of our efforts has been the development and dissemination of the WHONET software, a flexible, sophisticated, user-friendly tool for the management and analysis of microbiology test results. WHONET is utilized in over 90 countries by researchers, microbiologists, clinicians, public health epidemiologists, and national surveillance coordinators to manage, primarily at local and national level, results from over 1200 clinical, public health, veterinary, food, and academic laboratories for applications in basic science, clinical, and operational research; public health policy; clinical-decision support; and laboratory capacity- building. The objectives of this proposal are: a) to provide ongoing support to the existing WHONET software while integrating the latest in appropriate information technologies, ontologies, and informatics standards; b) to introduce significant enhancements to the WHONET analysis features in the areas of outbreak detection, data visualization, automation, notification, and information flow, and; c) to increase the effective utilization of WHONET by existing software users, to expand its use into new technical and geographical areas, and to promote data sharing in collaborative research networks. These developments will enhance the scientific and public health impact of our efforts and foster the strategic infrastructure required for collaborative research in developing and assessing infection and antimicrobial resistance containment interventions. Project Narrative: The continued emergence of infectious diseases, newly identified pathogens, and multi-drug resistant microorganisms is a global priority which threatens patient welfare worldwide and drains limited healthcare resources. The WHONET software, utilized in over 90 countries, provides researchers and public health authorities with tools for track emerging trends in infection and drug resistance and to develop and assess interventions for containment and control. The goal of this project is to expand WHONET in the areas of data sharing, outbreak detection, alert notification, and collaborative research in public health and scientific surveillance networks.