ALS RESEARCH GROUP DNA BANKING STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 肌萎缩侧索硬化症(ALS)及其相关的运动神经元疾病是一种进行性、破坏性的神经系统疾病，通常在3至5年内导致肌肉无力、呼吸衰竭和死亡。在大多数患者中，病因尚不清楚。肌萎缩侧索硬化症研究小组DNA Bank研究将着眼于可能有助于肌萎缩侧索硬化症发展的遗传因素。要做到这一点，研究人员需要血液样本以及来自ALS患者和对照组的一些与健康相关的基本病史和家族史信息。控制组是指没有肌萎缩侧索硬化症的人。这项研究将安全和匿名地收集血液样本以及与健康相关的病史和家族史，用于未来的ALS研究。美国和加拿大的10个ALS护理和研究中心和诊所，包括佛蒙特州大学，正在合作收集血液样本，并将其提交给位于新泽西州卡姆登的科里尔医学研究所的国家神经疾病和中风研究所(NINDS)人类遗传库。这项研究的结果将从ALS患者的血液样本中收集遗传物质，并为未来ALS病因的研究创造一个重要的全国性工具。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Amyotrophic lateral sclerosis (ALS) and its related motor neuron disorders are progressive, devastating neurological diseases causing muscle weakness, breathing failure, and death, usually within 3 to 5 years. In most patients, the cause is unknown. The ALS Research Group DNA Banking study will look at genetic factors which may contribute to the development of ALS. To do so, researchers need blood samples and some basic health-related medical and family history information from both ALS patients and controls. Controls are people who do not have ALS. This study will safely and anonymously collect blood samples and health-related medical and family history for future ALS research. A group of 10 ALS care and research centers and clinics in the United States and Canada, including the University of Vermont, are working together to collect and submit blood samples for DNA banking to the National Institute of Neurological Disorders and Strokes (NINDS) Human Genetics Repository at Coriell Medical Research Institute in Camden, NJ . The results of this study will provide a collection of genetic material from the blood samples of ALS patients, and create an important national tool for future studies on the causes of ALS.