HYDROXYCHOLOQUINE IN CYSTIC FIBROSIS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 需要检验的假设是，羟氯喹可降低CF患者治疗4周后诱导痰中的中性粒细胞、活性弹力酶和促炎细胞因子(无细菌负荷和增加细菌负荷)，并提高同时收集的呼气冷凝物(EBC)的pH值。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hypothesis to be tested is that hydroxychloroquine will reduce neutophils, active elastase, ad proinflammatory cytokines (without and increase in bacterial burden) in induced sputum after 4 weeks of therapy in patients with CF, and that it will increase the pH of exhaled breath condensate (EBC) collected at the same time points.