OMENTUM AND TREATMENT OF MORBID OBESITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这一应用的中心假设是，减肥手术后胰岛素敏感性的改善始于术后早期(10-30天)，并由能量相关肽的分泌变化介导，而长期影响(大于1个月)由炎症因子下调介导。具体目标1：确定RYGB治疗后代谢改善的机制 特定目标2：探索RYGB治疗后非洲裔美国人迟钝和迟缓代谢改善的机制 具体目标3：探索大网膜切除联合RYGB是否有助于加速和维持新陈代谢的改善，特别是在更难治的非裔美国人群体中

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The central hypotheses of this application is that improvements in insulin sensitivity following bariatric surgery begin early in the postoperative period (10-30 days) and are mediated by changes in the secretion of energy-related peptides, while the long-term effects (greater than 1 month) are mediated by down-regulation of inflammatory factors. Specific Aim 1: Determine the mechanism for the metabolic improvements after RYGB Specific Aim 2: Explore the mechanism for the blunted and delayed metabolic improvement after RYGB in African Americans Specific Aim 3: Explore whether combining omentectomy with RYGB helps accelerate and sustain metabolic improvements especially in the more refractory African American population