CHANGES IN PLASMA CONCENTRATIONS OF SUGARS AND SUGAR ALCOHOLS AFTER MILK FEEDING

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究将在喂养新生儿时检查母乳和配方奶粉中的一些糖和糖醇是否显示出餐后浓度增加的证据。单次饲喂乳汁后，将在饲喂后90分钟内检查葡萄糖、肌醇、甘油、山梨糖醇、山梨糖醇和甘露糖的浓度。仅通过母乳喂养摄入全部热量的婴儿将入组研究。每种糖和糖醇的摄入量将根据饲料体积以及用于喂养的牛奶中糖和醇的浓度来计算。将使用HPLC进行碳水化合物测量。 预计任何单一碳水化合物的餐后峰值的大小将是进食量和进食持续时间的函数。 该研究还将比较一组健康足月婴儿与一组“高危”婴儿的餐后糖和糖醇浓度，这些婴儿的母亲怀孕时患有既存或妊娠期糖尿病（IDM）或宫内生长受限（IUGR）。 已经证明，胎儿宫内发育迟缓（IUGR）孕妇的脐血流明显减少，这反过来又减少了胎儿的肝血流。 因此，在这些高风险婴儿中，喂养后肝脏对营养物质的摄取可能会显著受损。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study in feeding newborn infants will examine whether some of the sugars and sugar alcohols in breast milk and formula show evidence of a postprandial increase in concentration. After a single milk feeding, concentrations of glucose, inositol, glycerol, erythritol, sorbital and mannose will be examined over 90 minutes following the feeding. Only infants taking in full caloric intake by milk feedings will be enrolled in the studies. The intake of each sugar and sugar alcohol will be calculated from the volume of feed and the concentrations of the sugars and alcohols in the milk used for the feeding. HPLC will be used for the carbohydrate measurements. It is anticipated that the magnitude of the postprandial peak for any single carbohydrate will be a function of the volume of the feeding and the duration of the feeding. The study will also compare postprandial concentrations of the sugars and sugar alcohols in a group of healthy, term infants to a group of "high risk" infants who are born to mothers whose pregnancies were complicated by either pre-existing or gestational diabetes (IDM), or intrauterine growth restriction (IUGR). Umbilical blood flow has been demonstrated to be significantly reduced in IUGR pregnancies which, in turn, reduce fetal hepatic blood flow. Therefore, the hepatic uptake of nutrients after a feeding may be significantly compromised in these high risk infants.