WELL-NOURISHED AND SLEEPING PRETERM INFANT IMPROVED BRAIN DEVELOPMENT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这是一项由非营利基金会资助的针对极低出生体重早产儿的前瞻性对照临床试验。我们建议母乳的营养补充（和改良的感觉环境）可以改善早产儿的生长和大脑发育。我们的目标是改善极低出生体重早产儿的营养、睡眠质量、生长和大脑发育以及后期的神经发育结果。我们认为，改善营养的基础是：（1）确定母乳中的蛋白质和卡路里含量，（2）根据测量的含量对母乳进行强化。附加营养素的量必须根据被强化的牛奶的测定含量来个性化。通过这种方式，可以确保蛋白质和卡路里的摄入量保持在目标水平。我们还认为，在喂养过程中，循环的灯光和声音环境以及母乳气味的呈现也可能对婴儿有益。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a prospective, controlled clinical trial in very low birth weight (VLBW) preterm infants supported by non profit fundations. We propose that nutritional supplementation of breast milk (and a modified sensory environment) can improve growth and brain development of preterm infants. Our goal is to improve the nutrition, quantity of sleep, growth and brain development plus later neuro-developmental outcomes of VLBW preterm infants. We believe that improved nutrition is based on: (1) determination of the protein and calorie content of breast milk, and (2) fortification of mother's breast milk based on the measured contents. The amounts of additional nutrients must be individualized, based on the determined content of the milk that is being fortified. In this way it is possible to ensure that protein and calorie intake remains at a target level. We also believe that cycled light and sound environment and presentation of the mother's milk scent during feeding may also benefit the infant.