Protein Folding in the Cell

描述(由申请人提供)： 我们请求部分支持2008年、2010年和2012年美国实验生物学家协会联合会(FASE B)关于“细胞中的蛋白质折叠”的夏季会议。2008年会议将于2008年7月27日至8月1日在佛蒙特州萨克斯顿河举行。这次非常成功的会议是独一无二的，将细胞生物学家/遗传学家、生物物理学家/生物化学家和数学建模人员聚集在一起，解决蛋白质折叠和错误折叠的复杂问题及其对人类疾病的影响。这次会议对该领域发展的核心作用怎么估计都不为过。从历史上看，研究蛋白质折叠的生物物理化学家和关注蛋白质在体内生物发生的细胞生物学家之间并没有广泛的互动；然而，生物学问题的复杂性不仅需要了解细胞功能，还需要了解机制。现在，生物学家比以往任何时候都更多地探讨机制，而理论家则寻求与生物功能的联系。这次会议汇集了来自不同领域的尖端研究成果，以便进行思想交流。希望参加会议的新人络绎不绝，总是超额认购，这证明了这次会议的活力。每次会议都将重点放在蛋白质折叠的体内和体外机制，以及它们与细胞生物学、基因调控和人类疾病的基本过程之间的关系，同时还相当关注新的发展。因此，在2008年，大约一半的计划涉及蛋白质折叠的持久主题和执行这一过程的分子机器，以及蛋白质错误折叠引起的疾病，另一半讨论单分子折叠的新主题，在理解不同细胞间隔和位置的折叠方面的快速进展，以及新兴技术。我们通过这次会议的目标是将物理和生物科学家聚集在一个互动的环境中，促进教育和对方法、实验局限性的理解，并探索共同的兴趣。这次会议规模小，环境孤立，所有与会者都在附近居住和就餐，这促进了最佳的科学交流。会议形式将为非正式讨论提供广泛的场所。海报会议将允许所有参与者与其他调查人员进行科学互动。发言者中有很多年轻的调查人员和妇女，并鼓励他们参加会议，我们提出了增加少数群体与会者人数的战略。

DESCRIPTION (provided by applicant): We request partial support for the 2008, 2010 and 2012 Federation of American Society of Experimental Biologists (FASEB) Summer Conference on "Protein Folding in the Cell". The 2008 meeting will be held July 27 to August 1, 2008 in Saxtons River, VT. This extraordinarily successful meeting is unique in bringing together cell biologists/geneticists, biophysicists/biochemists, and mathematical modelers to tackle the complex problems of protein folding and misfolding and their implications for human disease. The extent to which this meeting is central to the development of the field cannot be overestimated. Historically, biophysical chemists who study protein folding and cell biologists concerned with protein biogenesis in vivo have not interacted extensively; however the complexity of the biological problems requires understanding mechanism as well as cellular function. Now, more than ever, biologists are approaching mechanism while the theorists are seeking ties to biological function. This is the meeting that brings together cutting edge research from diverse fields to allow for cross-fertilization of ideas. The vitality of this meeting is attested to by the fact that it is always oversubscribed with a constant stream of new people wishing to join the meeting. Each meeting maintains our core focus on in vivo and in vitro mechanisms of protein folding and how they relate to basic processes in cell biology, gene regulation and human disease, while devoting considerable attention to new developments. Thus, in 2008 about half of the program deals with the enduring themes of protein folding and the molecular machines that carry out this process, as well as diseases resulting from protein misfolding and the other half considers the new themes of folding of single molecules, the rapid progress in understanding folding in different cellular compartments and locations, and emerging technologies. Our goal through this meeting is to bring together physical and biological scientists in an interactive environment, to promote education and understanding of the approaches, experimental limitations and to explore common interests. The small size and isolated setting of this meeting with all participants residing and taking their meals in close proximity promotes optimal scientific exchange. The conference format will provide extensive arenas for informal discussions. Poster sessions will allow all participants to interact scientifically with other investigators. Young investigators and women are well-represented among speakers and encouraged to attend the conference and we propose strategies to increase the number of minority participants.