2nd Strategic Conference of Zebrafish Investigators

描述(由申请人提供)：第二届斑马鱼研究战略会议(美国阿西洛马尔，2007年2月2-6日)将是斑马鱼首席研究人员讨论当前研究和促进以FISH为模式系统的研究协调推进的第二次国际研讨会。随后将举行一系列两年期会议，第三次和第四次会议将于2009年2月和2011年2月举行。 斑马鱼是脊椎动物发育遗传分析的主要模式生物之一。它还迅速将自己确立为一个卓越的系统，在其中模拟人类出生缺陷和疾病，包括癌症。斑马鱼产生透明的胚胎，这些胚胎在母体外发育，既适合正向遗传分析，也适合反向遗传分析，从根本上说与其他脊椎动物相似。斑马鱼的胚胎学和遗传学分析为其他脊椎动物模式生物的研究提供了宝贵的补充，包括青蛙、雏鸟和老鼠。在斑马鱼身上进行的研究极大地丰富了我们对细胞命运决定和发育过程中形态发生过程的分子和细胞机制的理解。重要的是，斑马鱼也是了解器官发生和再生的一个很好的模型。因此，对斑马鱼突变的研究提供了新的疾病模型和疾病机制的剖析，也可能导致新的再生疗法。 2007年会议将包括所有与会者的口头和海报研究报告，以下列专题会议组织：1.模式形成；2.形态发生；3.分割和肌肉发生；4.神经发育；5.神经功能；6.基因组学；7.细胞通讯的分子机制；8-9。器官发生；10.鱼类研究的新领域；11.感官器官；12.疾病模型。社区会议将有助于评估鱼类研究的现状和未来方向。更多的讨论小组将提供一个平台，让社区中更有地位的成员指导初级鱼类调查人员。鱼类科学界发展非常迅速，目前由500多个实验室组成，涉及越来越多的研究领域。这次会议的目标是促进从事不同研究主题的主要研究人员之间加强沟通，并促进整个社区的凝聚力。在组织会议、挑选与会者的过程中，以及在整个会议期间，组织者将鼓励妇女、代表人数不足的少数群体和残疾人参加。

DESCRIPTION (provided by applicant): The 2nd Strategic Conference of Zebrafish Investigators (Asilomar, USA, February 2 - 6, 2007) will be the second international workshop for zebrafish principal investigators to discuss current research and promote coordinated advancement of research using fish as a model system. A series of biennial conferences will follow with the 3rd and 4th meetings to be organized in February of 2009 and 2011. The zebrafish is one of the premier model organisms for the genetic analysis of vertebrate development. It has also quickly established itself as an outstanding system in which to model human birth defects and diseases, including cancer. Zebrafish produce optically clear embryos that develop outside the mother, are suitable for both forward and reverse genetic analysis, and are fundamentally similar to other vertebrates. Embryological and genetic analyses in zebrafish provide a valuable complement to studies carried out in other vertebrate model organisms, including frog, chick, and mouse. Studies performed in zebrafish have greatly enriched our understanding of the molecular and cellular mechanisms underlying cell fate decisions and morphogenetic processes during development. Importantly, zebrafish are also an excellent model to understand organogenesis and regeneration. Thus, studies of zebrafish mutants offer new disease models and the dissection of disease mechanisms, and may also lead to novel regenerative therapies. The 2007 meeting will include oral and poster research presentations from all participants, organized in the following topical sessions: 1. Pattern formation; 2. Morphogenesis; 3. Segmentation and myogenesis; 4. Neural development; 5. Neural function; 6. Genomics; 7. Molecular mechanisms of cell communication; 8-9. Organogenesis; 10. New areas of fish research; 11. Sensory organs; and 12. Disease models. Community sessions will serve to assess the current state and future directions of fish research. Additional discussion groups will provide a platform for mentoring of the junior fish investigators by more established members of the community. The fish scientific community is growing very rapidly, currently comprising over 500 laboratories that address an increasing number of research areas. The goals of this meeting are to foster increased communication among principal investigators working on disparate research topics, and promote cohesiveness of the community as a whole. In the process of conference organization, selection of the participants, and throughout the conference, the organizers will encourage participation by women, underrepresented minorities, and persons with disabilities.