ASTHMA CONTROL EVALUATION (ACE): WEIGHT STUDY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 越来越多的证据表明肥胖是哮喘的一个危险因素，但人们对肥胖对哮喘患者健康状况的影响知之甚少。为了了解肥胖和哮喘之间的关系，测量体脂百分比和脂肪分布是很重要的。同样重要的是测量血液中与肥胖和炎症有关的物质（如瘦素）的水平。 ACE体重研究是一项在参与ACE研究的儿童和青少年哮喘患者中进行的肥胖、体脂百分比、脂肪分布和血液生物标志物与哮喘发病率关系的观察性研究。ACE参与者将接受关于他们的身体活动和饮食的采访。将进行生物电阻抗分析（测量体脂百分比和局部体脂）和双能X射线吸收测定法（骨密度的常规测试，也测量体脂）。将采集血样用于测量炎症标志物。这些活动将执行一次。将研究这些测量与哮喘发病率测量的关系，包括症状频率、哮喘加重频率、急性医疗保健利用和肺功能。 将邀请参与ACE研究（方案H23758）的研究受试者参与这项于2005年10月添加到ACE方案中的辅助体重研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Mounting evidence points to obesity as a risk factor for asthma, but little is known about the effects of obesity on the health status of patients with asthma. To understand the relationship between obesity and asthma, it is important to measure both the percent of body fat and the fat distribution. It is also important to measure blood levels of substances such as leptin that are related to obesity and inflammation. The ACE Weight Study is an observational study of the relationship of obesity, percent body fat, fat distribution, and blood biomarkers to asthma morbidity among children and adolescents with asthma participating in the ACE study. The ACE participants will be interviewed regarding their physical activity and diet. Bioelectrical impedance analysis (a measure of percent body fat and regional body fat) and Dual Energy X-ray Absorptiometry (a routine test for bone density that also measures body fat) will be performed. A blood sample will be collected for measurement of inflammatory markers. These activities will be performed once. These measurements will be studied in relation to measures of asthma morbidity including symptom frequency, asthma exacerbation frequency, acute health care utlilization, and pulmonary function. Research subjects participating in the ACE study, protocol H23758 will be invited to participate in this ancillary weight study that was added to the ACE protocol in October 2005.