ALOPECIA AREATA REGISTRY AND IMMUNOGENETIC MECHANISMS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 登记研究的目的是：1）确定大量患有斑秃或更严重形式（全秃和普秃）的受试者。 2)选择特定组的特征良好的受试者，以获得详细的临床数据、皮肤科医生检查、实验室研究、头皮数码照片、血清样本、白色血细胞和DNA。 将入组来自美国的特征明确的斑秃、AT或Au患者个体、同胞对和多重家系。 这些数据将被放置在一个关系数据库中，样本将被储存用于未来的研究。 3)提供数据和样本以检验AA是多基因踪迹的假设，并要求几个基因的相互作用以实现完全表达（Au/AT）加上环境触发因子。 4)进行关联研究，比较包括HLA在内的基因等位基因在AA不同表型中的频率差异。 5)探讨AA在同胞对和多发病家系中的遗传标记。 只有国家登记处才能提供收集大量患者资料所需的资源类型。 GCRC将通过提供临床可用性来帮助该项目，以容纳大量参与者，最大限度地降低参与登记研究的参与者的成本，并简化临床数据收集。 数据仍将在德克萨斯州休斯顿的中心站点进行处理和分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the Registry is: 1) To identify large numbers of subjects who have alopecia areata or more severe forms (alopecia totalis and universalis). 2) To select specific groups of well-characterized subjects for detailed clinical data, dermatoligist's exam, lab studies, digital photos of the scalp, sera samples, white blood cells, and DNA. Individual patients, sib-pairs, and multiplex families from the United States with well-characterized alopecia areata, AT or AU will be entered. Thte data will be placed in a relational database and the samples will be banked for future research studies. 3) To provide data and samples to test the hypothesis that AA is a multigenic trail and request the interaction of several genes for full expression (AU/AT) plus an environmental trigger factor. 4) To conduct association studies that compare differences in precent frequency of alleles of genes including HLA in the different phenotypes of AA. 5) To examine the inheritance markers with AA in sib-pairs and multiplex families with multiple affected individuals. Only a natinoal registry can provide the type of resources needed to collect this large number of patient material. The GCRC will aid this project by providing clinical availability to accomodate the large number of participants, minimize the cost to participants involved in the registry, and streamline the data collection in clinic. The data will still be processed and analyzed at the central site in Houston, TX.