INSULIN RECEPTOR POSITIVE AND AUTOANTIGEN REACTIVE T CELLS IN TYPE 1 DIABETES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的目的是分析1型糖尿病患者、1型糖尿病高危亲属和低危亲属、其他自身免疫性疾病患者和正常健康对照的外周血免疫细胞特征，并测定体液免疫反应。研究对象的基因分析将包括人类白细胞抗原分型。具体地说，但不是唯一的，我们将研究外周血中胰岛素受体阳性细胞和抗原反应细胞的作用，特别强调调节性细胞和其他特殊细胞群体、血清自身抗体和疾病易感性。 这项研究有可能找到人类1型糖尿病的细胞标志物，并让我们更好地了解疾病过程本身。监测自身免疫活动的能力也可以帮助任何未来的干预工具。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to analyze the characteristics of peripheral blood immune cells and measure humoral immune responses in Type 1 diabetes patients, relatives at high risk and relatives at low risk for developing Type 1 Diabetes, patients with other autoimmune diseases and normal, healthy control individuals. The study subjects' genetic analysis will include HLA typing. Specifically, but not exclusively, we will look at the role of insulin receptor positive and antigen reactive cells in the peripheral blood, with special emphasis on regulatory and other specialized cell populations,serum autoantibodies and disease predisposition. The study has the potential to find a cellular marker for human Type 1 diabetes mellitus and also to give us a better understanding of the disease process itself. The ability to monitor the activity of autoimmunity could help any future interventional tools too.