BIOBEHAVIORAL EFFECTS OF MINDFULNESS-BASED STRESS REDUCTION IN HIV

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们建议确定基于正念的减少(MBSR)计划是否在以下方面比压力和应对写作控制条件(SCW)更有效：(1)提高免疫抵抗力和延缓HIV疾病的进展(即T淋巴细胞亚群的增加和病毒载量的减少)，(2)改善心理状态和生活质量，以及(3)确定这些影响是否通过练习的数量和正念的变化来调节。我们假设，与迄今为止的证据一致，(1)MBSR训练将导致免疫状态的更大改善，其指标是T淋巴细胞的增加，(2)尽管到目前为止还没有证据表明MBSR对艾滋病毒的临床有效性，但我们假设，与对照条件相比，正念训练将产生更大的病毒负荷减少，以及(3)正念训练将比对照条件更大地改善心理状态和幸福感。最后，我们还假设(4)，免疫力和心理变化的大小将通过练习的数量来缓和，并通过正念的增加来调节。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to determine whether the Mindfulness-Based Reduction (MBSR) program is more effective than a stress and coping writing control condition (SCW) in: (1) improving immune resistance and delaying HIV disease progression (i.e. increases in T-lymphocyte subsets and reductions in viral load), (2) improving psychological status and quality of life, and (3) to determine whether these effects are moderated by the amount of practice and mediated by changes in mindfulness. We hypothesize, consistent with the evidence to date, that: (1) MBSR training will elicit greater improvements in immune status as indexed by increases in T-lymphocytes than the control condition, (2) although there is no evidence of the clinical effectiveness of MBSR with HIV to date, we hypothesize that mindfulness training will produce greater reductions in viral load compared to the control condition, and (3) that mindfulness training will produce greater improvements in psychological status and well-being than the control condition. Finally, we also hypothesize (4) that the magnitude of immune and psychological changes will be moderated by the amount of practice and mediated by increases in mindfulness.