A COMPARISON OF HYDROCHLOROTHIAZIDE AND METOLAZONE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本方案的目的是确定哪种利尿剂组合在促进充血性心力衰竭患者利尿方面最有效。 次要目的：确定呋塞米单药治疗和与氢氯噻嗪或美托拉宗联合治疗的作用持续时间。 确定利尿剂联合治疗对神经激素激活的影响。 确定美托拉宗和氢氯噻嗪对预测室性心律失常参数的相对影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this protocol is to establish which combination of diuretics is the most effective in promoting diuresis in congestive heart failure patients. Secondary Objectives: To determine the duration of action of furosemide as monotherapy and in combination with either hydrochlorothiazide or metolazone. To determine the effect of diuretic combination therapy on neurohormonal activation. To determine the relative influence of metolazone and hydrochlorothiazide on parameters predicting venticular arrhythmias.