RESEQUENCING THE VARIABLE HUMAN GENOME IN SPORADIC ALS: A NECESSARY PRELUDE TO

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 肌萎缩侧索硬化症和相关的运动神经元疾病是导致肌肉无力的神经系统疾病。在大多数患者中，病因不明，也没有有效的治疗方法。为了研究一个人的遗传物质中可能的原因，西部肌萎缩侧索硬化症协会[WALS]的研究人员需要从患者那里获得血液样本和一些与健康相关的基本病史和家族史信息。本研究正在收集血液样本和信息，为有针对性地研究ALS的病因提供信息，旨在为ALS的靶向药物治疗提供依据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Amyotrophic lateral sclerosis and related motor neuron disorders are neurological diseases that cause muscle weakness. In most patients, the cause is unknown and no effective treatment exists. To study possible causes in a person's genetic material, the Western ALS Consortium [WALS] researchers need blood samples and some basic health-related medical and family history information from patients. This study is collecting the blood samples and information for targeted research into the causes of ALS aiming towards targeted drug treatment in ALS.