THE EFFECT OF ETHANOL ON OVERNIGHT GLUCOSE REGULATION IN TYPE 2 DIABETES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 中等剂量的乙醇通过干扰一个或几个对低血糖防御至关重要的生理过程，导致需要胰岛素的老年2型糖尿病患者的夜间低血糖脆弱性。 在这项研究中调查的变化是加重了不足的反调节反应，低血糖通常发生在睡眠期间。 在12名老年健康受试者和12名需要胰岛素的2型糖尿病老年受试者中，比较口服和静脉注射中等剂量乙醇或安慰剂对睡眠期间胰岛素诱导的低血糖的反调节激素释放和恢复的过夜效应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Moderate doses of ethanol cause overnight hypoglycemic vulnerability in elder, insulin requiring patients with type 2 diabetes by interfering with one or several of the physiologic processes critical to the defense against hypoglycemia. The alteration investigated in this study is exacerbation of the deficient counterregulatory response to hypoglycemia that occurs normally during sleep. To compare the overnight effects of moderate doses of both orally and intravenously administered ethanol or placebo on counterregulatory hormone release and recovery from insulin-induced hypoglycemia during sleep among 12 elder healthy and 12 elder subjects with insulin requiring type 2 diabetes.