GENOTYPE-PHENOTYPE INTERACTIONS IN SEVERE ASTHMA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 哮喘在美国是一种常见的慢性肺部疾病，影响1700多万人。这是一种呼吸道炎症，其原因尚不完全清楚。尽管使用了大剂量的吸入或口服皮质类固醇(减少呼吸道炎症的药物)，约有10%的哮喘患者仍有持续的症状。这组研究检查了哮喘患者肺部的基因和细胞/液体，以更好地了解为什么某些人的哮喘更严重。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Asthma is a common chronic lung disease in the United States, affecting more than 17 million persons. It is an inflammatory condition of the airways whose cause is not completely understood. Approximately 10% of asthmatics have "severe asthma" with continuous symptoms despite the use of high doses of inhaled or oral corticosteroids (medications to reduce inflammation in the airways). This group of studies examines genes and cells/fluid from lungs of people with asthma to better understand why asthma is more severe in some people.