How do thick airway walls affect airway hyperresponsiveness in asthma?

气道壁厚如何影响哮喘气道高反应性？

• 批准号: nhmrc : 512387
• 负责人: Dr Cheryl Salome
• 金额: $ 25.51万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/thick-airway-walls-hyperresponsiveness-asthma/96680
• 关键词: How; do; thick; airway; walls

Asthmatic airways narrow too easily, a characteristic called airway hyperresponsiveness (AHR). To understand the cause of asthma we need to understand the cause of AHR. Thickened airway walls could amplify airway narrowing and increase AHR. However, thick airway walls are also stiff, and stiff walls could reduce narrowing and AHR. This project will examine the relationships between AHR and airway wall thickness and stiffness during and after treatment that reduces airway wall thickness.

哮喘患者的呼吸道太容易变窄，这一特征被称为气道高反应性(AHR)。要了解哮喘的病因，我们需要了解AHR的病因。气道壁增厚可放大气道狭窄，增加AHR。然而，厚厚的气道壁也是僵硬的，坚硬的管壁可以减少狭窄和AHR。本项目将研究AHR与减少气道壁厚度的治疗期间和治疗后的气道壁厚度和僵硬之间的关系。