MECHANISMS MEDIATING CARDIOVASCULAR DISEASE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是通过研究阻塞性睡眠呼吸暂停儿童血压控制和心脏大小及功能的差异，了解睡眠呼吸暂停对心脏和血压的影响。我们还研究了阻塞性睡眠呼吸暂停治疗对血压控制以及心脏大小和功能变化的影响，并与无阻塞性睡眠呼吸暂停的儿童进行了比较。 这是一项为期一年的研究，将包括一次筛选访视和四次研究访视，分别在访视1、治疗后6周、治疗后6个月和治疗后1年进行。对于符合资格的受试者，每名受试者将有3-4次过夜停留（取决于受试者被置于哪个研究组），其中包括多导睡眠图（睡眠研究）、三台超声心动图和四次家庭24小时动态血压测试。我们的研究包括测量呼吸，血压，睡眠质量，心脏大小和功能。 参与者是从6-13岁的儿童中招募的，他们患有疑似阻塞性睡眠呼吸暂停（OSA），并且仍然有扁桃体或腺样体。这些儿童将与6-13岁的儿童对照组相匹配，这些儿童没有打鼾或OSA症状，并且在过去两年内没有切除扁桃体或腺样体。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to understand the effect of sleep apnea on the heart and blood pressure by studying the differences in control of blood pressure and the size and function of the heart in children with obstructive sleep apnea. We are also studying the effect of treatment of obstructive sleep apnea on these changes in blood pressure control and the size and function of the heart in comparison to children without obstructive sleep apnea. This is a one-year study that will involve a screening visit and four study visits spaced at visit 1, 6 weeks post treatment, 6 months post treatment, and 1 year post treatment. For subjects who qualify, each subject will have 3-4 overnight stays (depending on which study group the subject is placed) that includes a polysomnography (sleep study), three echocardiographs, and four home 24-hour ambulatory blood pressure tests. Our study involves measuring breathing, blood pressure, sleep quality, and heart size and function. Participants are recruited from children ages 6-13 years with suspected obstructive sleep apnea (OSA) and who still have their tonsils or adenoids. These children will be matched with a control group of children ages 6-13 who do not snore or have symptoms of OSA and who have not had their tonsils or adenoids removed within the past two years.