EPITHELIAL CELLS AND CHRONIC RHINOSINUSITIS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 慢性鼻窦炎(CRS)是一种常见疾病，影响15%的总人口，每年造成超过60亿美元的损失。CRS的发病机制以黏膜上皮细胞和T细胞活化的炎症为特征。鼻腔上皮细胞表达B7共刺激分子，这是一种介导T细胞激活的专门分子。这些研究人员假设，与CRS相关的炎症改变了B7同系物和其他特殊分子的表达，这些分子介导了上皮细胞和T细胞之间的交流。此外，假设上皮细胞表面分子可以作为疾病的标志，鼻窦疾病的恶化将与上皮共刺激因子的表达增加有关。本研究的主要目的是了解CRS的基本病理生理学。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chronic Rhinosinusitis (CRS) is a common disease affecting 15% of the general population and costing in excess of $6 billion annually. The pathogenesis of CRS is characterized by mucosal inflammation with activated epithelial cells and T cells. Nasal epithelial cells express B7 co-stimulatory molecules, specialized molecules that mediate T cell activation. These investigators hypothesize that inflammation associated with CRS alters the expression of B7 homologs and other specialized molecules that mediate the communication between epithelial cells and T cells. Furthermore, it is postulated that epithelial cell surface molecules can serve as markers of disease and that exacerbation of sinonasal disease will be associated with increased expression of epithelial co-stimulators. The overarching goal of this research is to understand the basic pathophysiology of CRS.