LUNG CHANGES IN YOUNG ADULTS WITH MODERATE TO SEVERE ASTHMA-HRCT SCANS, METHACHS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 儿童哮喘研究（CAS）是一项随机、设盲、安慰剂对照的广谱过敏原免疫治疗试验，确定了一组患有中度至重度哮喘的年轻人，他们现在有持续的肺功能缺陷。 为了进一步描述这些功能缺陷的性质，这些研究者提出了一项三部分研究，以检查这些受试者的肺解剖学和病理生理学，包括气道高分辨率CT扫描（HRCT）、乙酰甲胆碱激发试验、诱导痰（IS）和呼出冷凝液研究（EBC）。 这些研究者假设，持续性肺功能缺损的受试者将通过CT扫描上气道增厚增加和扩张性降低、乙酰甲胆碱敏感性表示的气道高反应性增加以及IS和EBC采样上炎性标志物增加的证据与其他队列成员区分开。 这些研究对儿童哮喘的监测和预后具有重要意义。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Childhood Asthma Study (CAS), a randomized, masked, placebo controlled trial of broad spectrum allergen immunotherapy, identified a group of young adults with moderate to severe asthma who now have persistent lung function deficits. In order to characterize the nature of these functional deficits further, these investigators propose a three part study to examine the lung anatomy and pathophysiology in these subjects including high resolution CT scanning of the airways (HRCT), methacholine challenge tests, and induced sputum (IS) and exhaled condensate studies (EBC). These investigators hypothesize that subjects with persistent lung function deficits will be distinguishable from other cohort member by evidence of increased airway thickening and reduced distensibility on CT scans, increased airway hyperreactivity as expressed by methacholine sensitivity, and increased inflammatory markers on IS and EBC sampling. These studies have important implications for monitoring and prognosis of childhood asthma.