CLINICAL TRIAL OF IMMUNOTHERAPY WITH A CANDIDATE EXTRACT OF NON-AMMONIATED LATEX

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的主要原因是确定乳胶过敏症患者注射乳胶过敏疫苗的一般安全性和有效性。完全避免乳胶是目前治疗过敏者的唯一方法，如果不改变职业，这通常是不可能实现的，这可能会对经济产生影响，有时也是卫生保健专业人员和其他人不能接受的。此外，一些研究表明，搬到一个没有乳胶或乳胶最少的新环境可能不足以避免持续的症状或帮助治疗呼吸道疾病。因此，需要额外的选择是非常重要的。有理由相信，与传统过敏疫苗类似的常规乳胶疫苗治疗，可能会在减少乳胶过敏方面取得成功。 在这项研究中，我们将通过收集几种测试方法的证据来监测乳胶疫苗对受试者免疫系统的影响。血液工作、皮肤测试和呼吸乳胶颗粒挑战的结果将是我们将使用的测试方法。这项研究的结果将告诉我们，对于医护人员和乳胶过敏患者，这是否是一种实用、有效和安全的可能治疗形式。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary reason for this study is to determine the general safety and effectiveness of latex allergy shots in latex allergic individuals. Complete avoidance of latex is the only current remedy for those that are allergic and this is often immpossible to achieve without an occupational change which could be economically impacting as well as sometimes unacceptable to health care professionals and others. Furthermore, some studies suggest that moving to a new environment where latex is absent or minimal may not be enough to avoid continuing symptoms or to help with respiratory disease. The need for additional options is therefore very important. There is reason to believe that treatment with regular latex shots similar to traditional allergy shots, may be successful in reducing latex allergy. During this study, we will monitor the effects of the latex shots on the immune systems of our subjects by gathering evidence from several testing methods. Results from blood work, skin testing and challenges of breathing latex particles will be the testing methods we will be using. The results of this study will tell us if this is a practical, effective and safe form of possible treatment for health care workers and people with latex allergy.