PHYSICAL ACTIVITY, PAIN AND FUNCTION IN CANCER SURVIVORS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究已接近应计。 被诊断患有癌症的人中，超过一半的人可以存活五年以上。然而，关于老年癌症幸存者的长期结果，包括功能限制的发展，可获得的信息有限。目前的研究检查了与功能受损相关的可改变的风险因素，包括体力活动、疼痛和炎症。这项横断面分析将使用调查方法来评估745名65岁或以上的结直肠癌幸存者(确诊后5-10年)的体力活动、疼痛和身体功能，这些人通过威斯康星州癌症登记中心确认，并通过国家死亡指数进行了验证。这些结构的标准测量工具将通过邮寄的调查问卷进行管理。此外，一种新开发的量表将作为调查单元的一部分进行管理，该量表评估身体功能的其他维度以及功能限制的潜在原因，试图验证这一测量在未来用于老年长期癌症幸存者。为了解决炎症在身体活动、疼痛和功能关系中是否起到中介作用，并进一步验证新的功能量表，我们将从我们的人群中抽取一组样本(n=35)进行客观的身体功能和身体成分测试，并抽取血液进行炎症标记物(C-反应蛋白、白细胞介素6、肿瘤坏死因子-α)的测量。确定与身体功能相关的可改变的危险因素对于改善日益增长的老年癌症幸存者的长期功能结果具有重要意义。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is closed to accrual. More than half of those diagnosed with cancer will survive longer than five years. Limited information, however, is available regarding long-term outcomes of older cancer survivors, including the development of functional limitations. The current study examines modifiable risk factors associated with impaired functioning including physical activity, pain, and inflammation. This cross-sectional analysis will use survey methods to assess physical activity, pain, and physical function in 745 survivors of colorectal cancer (5-10 yrs post-diagnosis) who are aged 65 or older, identified through the Wisconsin Cancer Registry and verified as living through the National Death Index. Standard measurement tools for each of these constructs will be administered via a mailed questionnaire. Additionally, a newly developed scale that assesses additional dimensions of physical function as well as the potential causes of functional limitations will be administered as part of the survey battery in an attempt to validate this measure for future use with older long-term cancer survivors. To address whether inflammation plays a mediating role in the physical activity, pain, and function relationships, and to further validate the new function scale, we will bring a sub-sample (n=35) of our population in for objectively measured physical function and body composition testing and a blood draw from which markers of inflammation (C-reactive protein, interleukin-6, tumor necrosis factor-alpha) will be measured. Identifying modifiable risk factors associated with physical function has important implications for improving long-term functional outcomes in the growing population of older cancer survivors.