EFFECT OF HEPATITIS C ON INSULIN RESISTANCE IN CHILDREN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 A. 具体目的/目标 将研究一组年龄、性别、体重指数（BMI）和坦纳分期匹配的HCV感染儿童和健康对照儿童，以评估是否： 1)丙型肝炎病毒感染与儿童胰岛素抵抗相关 2)清除HCV感染可改善儿童IR 3)HCV感染与较高的TNF-α和较低的脂联素水平相关，而这些又与IR相关，既有横截面，也有纵向 通过上述目标，将检验以下假设： 1)丙型肝炎病毒感染与儿童胰岛素抵抗相关 2)清除HCV感染可降低儿童IR 3)炎症性脂肪因子介导HCV相关IR的发生

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A. Specific Aims /Objectives A cohort of children with HCV infection and healthy controls matched for age, gender, body mass index (BMI), and Tanner stage will be studied to evaluate whether: 1) HCV infection is associated with IR in children 2) Clearance of HCV infection improves IR in children 3) HCV infection correlates with higher TNF-alpha and lower adiponectin levels and these, in turn, correlate with IR both cross-sectionally as well as longitudinally Through the above aims, the following hypotheses will be tested: 1) HCV infection is associated with IR in children 2) Clearance of HCV infection reduces IR in children 3) Inflammatory adipokines mediate the development of HCV-associated IR