NEUROIMAGING IN THE OKLAHOMA FAMILY HEALTH PATTERNS PROJECT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：酒精中毒（FH+）和行为去抑制的阳性家族史都与发展为酒精使用障碍的风险增加有关。 俄克拉荷马州家庭健康模式项目旨在研究健康、非滥用FH+的人，这些人也显示出行为控制不足（高风险）的证据。 我们假设，这些高风险的人将表现出改变边缘系统活动，以响应情绪上的重大刺激，相对于低风险的个人（FH-和缺乏行为控制）。 研究方法：为了验证这一论断，我们将在主要研究中从更大的队列中选择高风险人群和低风险人群进行有针对性的fMRI实验。 受试者将参与面部识别任务，使用显示负面情绪的面部，并测量大脑激活区域。 临床相关性：边缘系统低反应性可能与愿意做出关于酒精摄入的危险决定有关，增加了人对酒精滥用的责任。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. OBJECTIVE: A positive family history of alcoholism (FH+) and behavioral disinhibition are both associated with increased risk of developing an alcohol use disorder. The Oklahoma Family Health Patterns project was designed to study healthy, nonabusing FH+ persons who also display evidence of behavioral undercontrol (High Risk). We hypothesize that these High-Risk persons will demonstrate altered limbic system activity in response to emotionally significant stimuli, relative to Low-Risk individuals (FH- and lacking in behavioral undercontrol). RESEARCH PLAN AND METHODS: To test this assertion, we will carry out a targeted fMRI experiment on High-Risk persons and Low Risk persons chosen from a larger cohort in the primary study. The subjects will participate in a facial recognition task using faces displaying negative emotions and regions of brain activation will be measured. CLINICAL RELEVANCE: Limbic hyporesponsiveness may be associated with a willingness to make risky decisions about alcohol intake increasing the person's liability for alcohol abuse.