NEUROIMAGING IN THE OKLAHOMA FAMILY HEALTH PATTERNS PROJECT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：阳性的酗酒家族史(FH+)和行为去抑制都与发展成酒精使用障碍的风险增加有关。俄克拉荷马州家庭健康模式项目旨在研究健康的、不滥用FH+的人，这些人也表现出行为控制不足(高风险)的证据。我们假设这些高危人群将表现出边缘系统活动的改变，以回应情绪上的重要刺激，相对于低危个体(FH-和缺乏行为失控)。 研究计划和方法：为了验证这一断言，我们将在初步研究中从更大的队列中选择高风险人群和低风险人群进行有针对性的功能磁共振实验。受试者将参与一项面部识别任务，使用显示负面情绪的面孔，并测量大脑激活的区域。 临床相关性：边缘低反应可能与愿意对酒精摄入量做出冒险决定有关，增加了个人酗酒的风险。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. OBJECTIVE: A positive family history of alcoholism (FH+) and behavioral disinhibition are both associated with increased risk of developing an alcohol use disorder. The Oklahoma Family Health Patterns project was designed to study healthy, nonabusing FH+ persons who also display evidence of behavioral undercontrol (High Risk). We hypothesize that these High-Risk persons will demonstrate altered limbic system activity in response to emotionally significant stimuli, relative to Low-Risk individuals (FH- and lacking in behavioral undercontrol). RESEARCH PLAN AND METHODS: To test this assertion, we will carry out a targeted fMRI experiment on High-Risk persons and Low Risk persons chosen from a larger cohort in the primary study. The subjects will participate in a facial recognition task using faces displaying negative emotions and regions of brain activation will be measured. CLINICAL RELEVANCE: Limbic hyporesponsiveness may be associated with a willingness to make risky decisions about alcohol intake increasing the person's liability for alcohol abuse.