INFLAMMATORY RESPONSE TO DIETS BETWEEN ASIANS AND CAUCASIANS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究的假设是，与白人相比，亚裔美国人从传统的亚洲饮食转变为典型的美国饮食时，患上促炎状态的风险更高，这可能导致心脏病和糖尿病的发展。这些炎症反应将通过单核细胞的活化来反映，如通过蛋白激酶C PKC（一种已知的单核细胞活化剂）所测量的。假设龈沟液GCF中的这些炎症反应将反映血浆和单核细胞中这些标记物的类似变化。本研究的具体目的是比较炎症反应的主要PKC激活单核细胞之间，远东亚裔美国人和高加索美国人，当他们从传统的亚洲饮食改变到一个典型的美国饮食，并在血浆和单核细胞炎症反应的生化变化与龈沟液。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hypothesis of this study is that Asian Americans compared to Caucasians, will be at higher risk of developing a pro-inflammatory state that may contribute to the development of heart disease and diabetes when they change from a traditional Asian diet to a typical American diet. These inflammatory responses will be reflected by the activation of monocytes as measured by protein kinase C (PKC), a known activator of monocytes. It is hypothesized that these inflammatory responses in the gingival crevicular fluid (GCF) will reflect similar changes of these markers in the plasma and monocytes. The specific aims of this study are to compare the inflammatory responses (primary PKC activation in monocytes), between Far-East Asian Americans and Caucasian Americans, when they change from a traditional Asian diet to a typical American diet and also to correlate the biochemical changes of inflammatory responses in the plasma and monocytes with those in the gingival crevicular fluid.