REGULATION OF PLATELET FUNCTION BY GPIIB-IIIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 整合素受体家族的成员在诱导黏附中发挥关键作用，并参与许多需要黏附诱导细胞行为改变的事件。例如，跨整合素的信号参与血管生成、发育、转移、炎症、伤口愈合和止血。我们研究的总体目标是了解导致整合素激活和整合素诱导的细胞行为变化的信号通路。预计这些研究将提供有关整合素双向信号传递机制的信息。此外，这些研究可能有助于加深对整合素介导的功能的关键机制的理解，如血小板黏附和聚集、伤口愈合、血管生成、炎症、转移和细胞迁移。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Members of the integrin family of receptors play a critical role in inducing adhesion and are involved in numerous events that require adhesion-induced changes in cell behavior. For example, signaling across integrins is involved in angiogenesis, development, metastasis, inflammation, wound healing, and hemostasis. The overall goal of our research is to understand the signaling pathways leading to integrin activation and to integrin-induced changes in cell behavior. It is anticipated that these studies will provide information on mechanisms involved in two-way signaling across integrins. Further, the studies may lead to an increased understanding of key mechanisms involved in integrin-mediated functions such as platelet adhesion and aggregation, wound healing, angiogenesis, inflammation, metastasis, and cell migration.