COBRE: WVU: SIGNAL TRANSDUCTION & CANCER: ADMINISTRATIVE CORE

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 癌症不成比例地影响西弗吉尼亚州和阿巴拉契亚的公民，宫颈癌、肺癌、头颈癌、卵巢癌和乳腺癌的健康差异就是明证。玛丽巴布兰多夫癌症中心（MBRCC）成立于西弗吉尼亚大学，以解决我们地区的癌症问题。 为了实现这一目标，我们计划建立一个符合NCI指定标准的癌症中心，作为我们服务不足的人群的临床癌症中心。 NCI指定的癌症中心的建立是为了领导与癌症的斗争，这体现在：（a）强大的基础和临床研究计划，（B）积极的癌症预防和控制计划，以及（c）积极的临床试验计划。 我们的Cobre计划的第一阶段（第一阶段）的目标是通过发展强大的和互动的基础癌症研究计划来促进这些机构的目标。 在第一阶段，MBRCC协调癌症中心成员和项目组织，为试点项目、核心设施和实验室/办公空间提供匹配支持。 此外，西弗吉尼亚大学健康科学中心承诺为新的教职员工提供终身教职，并为启动包、行政支持、实验室和核心设施的翻新以及核心设备的资金提供资源。 在第一阶段，COBRE为五个初级教师基础研究项目提供支持，为新的和现有的教师提供核心设施基础设施，并为教师招聘提供匹配资金。 在COBRE的第一阶段，我们成功地招募了8名新教师，指导5名初级教师获得独立研究项目资助（RPG）资金，建立了两个新的核心设施，并扩大了第三个核心设施的范围。 在这次更新申请（第二阶段）中，我们寻求增加基础科学研究项目的深度，长期目标是将基础研究项目与转化研究项目相结合。 第二阶段的具体目标是（a）保持一个管理核心，指导和发展的CobRE计划（B）支持3个核心设施，在流式细胞术，蛋白质组学和生物信息学，促进我们的研究计划和（c）支持五个初级教师的研究项目，并指导这些教师的独立性。 行政核心（目标1）将监督这项工作。 该Cobre计划将促进我们实现NCI指定为临床癌症中心的长期目标，为西弗吉尼亚州和周边阿巴拉契亚地区的患者群体提供服务。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cancer disproportionately affects the citizens of West Virginia and Appalachia, as evidenced by health disparities in cervical, lung, head & neck, ovarian and breast cancers. The Mary Babb Randolph Cancer Center (MBRCC) was established at West Virginia University to address the cancer problem in our region. Toward that goal we plan to establish a cancer center that meets the criteria for NCI designation as a Clinical Cancer Center for our underserved population. NCI designated Cancer Centers were established to lead the fight against cancer as evidenced by (a) strong basic and clinical research programs, (b) an active cancer prevention and control program and (c) an active clinical trials program. The goal of the first phase (Phase I) of our CoBRE program was to foster these institutional goals through the development of strong and interactive basic cancer research programs. In Phase I, the MBRCC coordinated cancer center membership and organization of programs, provided matching support for pilot projects, core facilities and lab/office space for new faculty hires. In addition, the West Virginia University Health Sciences Center committed tenure-track faculty lines for new faculty hires and resources for startup packages, administrative support, renovations for labs and core facilities and funds for core equipment. During Phase I, the CoBRE provided support for five junior faculty basic research projects, core facility infrastructure for new and existing faculty and matching funds for faculty recruitment. In Phase I of the CoBRE, we were successful in recruiting 8 new faculty members, mentoring 5 junior faculty members to independent research project grant (RPG) funding, establishing two new core facilities and expanding the scope of a 3rd core facility. In this renewal application (Phase II), we seek to add depth to our basic science research programs with a long term goal of integrating basic research projects with translational research programs. The Specific Aims of Phase II are to (a) maintain an Administration Core that guides and develops the CoBRE program (b) support 3 core facilities in Flow Cytometry, Proteomics and Bioinformatics that foster our research programs and (c) support five junior faculty research projects and mentor these faculty members to independence. The Administration core (Aim #1) will oversee this effort. This CoBRE program will foster our long term goal of achieving NCI designation as a Clinical Cancer Center that serves the patient population of West Virginia and the surrounding Appalachian region.