ANALYSIS OF BONE HEALTH IN AFRICAN AMERICAN CHILDREN WITH DISTAL FOREARM

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 假设1：对环境概况、人体测量数据和饮食的分析将证明，与骨骼健康状况不佳有关的流行病学风险因素与非裔美国儿童的创伤性前臂骨折显著相关。这些因素包括与维生素D缺乏和体重指数增加有关的因素。我们将确定和比较这些群体中的社会人口学/环境概况、人体测量数据和饮食风险因素。 假设2：对维生素D缺乏的生化指标的分析表明，在患有创伤性前臂骨折的非裔美国儿童中，至少有10%的维生素D缺乏水平。这一特定目标的目的是确定和比较每一组中亚临床维生素D缺乏/维生素D不足的存在。 假设3：双能X射线骨密度仪(DEXA扫描)测量将证明低骨密度和/或骨矿含量与非裔美国儿童创伤性前臂骨折有关。使用DEXA扫描，我们将在每个研究组的子集中测量骨矿含量和密度。这一特定目标的目的是识别和比较每一组中异常的骨矿物质含量和密度。 假设4：与骨骼健康/质量相关的基因多态，如维生素D受体多态，与没有骨折的对照组相比，与非裔美国儿童创伤性前臂骨折的风险增加相关。利用GCRC遗传学核心，将对个体进行与骨骼健康/质量相关的蛋白质多态的基因分型。将进行AIMS 1-3中描述的每种多态与骨健康不良相关因素之间的相关性测试。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypothesis 1: An analysis of environmental profiles, anthropometric data and diet will demonstrate that epidemiological risk factors linked with poor bone health are significantly associated with traumatic forearm fractures in African American children. These include factors associated with vitamin D deficiency, and increased body mass index. We will identify and compare sociodemographic/environmental profiles, anthropometric data and dietary risk factors in the groups. Hypothesis 2: An analysis of biochemical indicators of Vitamin D deficiency will demonstrate that at least ten percent of African American children with traumatic forearm fractures have deficient levels. The goal of this specific aim is to identify and compare the presence of subclinical vitamin D deficiency/vitamin D insufficiency in each of the groups. Hypothesis 3: Dual energy x-ray absorptiometry (DEXA scan) measurements will demonstrate that low bone density and/or bone mineral content is associated with traumatic forearm fractures in African American children. Using DEXA scan, we will measure bone mineral content and density in a subset of each of the study groups. The goal of this specific aim is to identify and compare abnormal bone mineral content and density in each of the groups. Hypothesis 4: Genetic polymorphisms in genes related to bone health/quality, such as the vitamin D receptor polymorphism, are associated with increased risk of traumatic forearm fractures in African American children compared with fracture-free controls. Using the GCRC Genetics Core, genotyping of individuals for protein polymorphisms related to bone health/quality will be done. Testing for correlation between each polymorphism and factors associated with poor bone health described in aims 1-3 will be performed.