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Mitochondrial chaperones: Import of membrane-spanning precursors through the inter-membrane space

Mitochondrial chaperones: Import of membrane-spanning precursors through the inter-membrane space
线粒体伴侣:通过膜间空间导入跨膜前体
批准号:
nhmrc : 516713
负责人:
Dr Jacqueline Gulbis
金额:
$21.88万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31

项目摘要

项目成果

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中文摘要
翻译
所有的细胞蛋白质都是在核糖体上合成的。然后,高度调节的运输系统将它们在细胞内移动。专门的“转座”介导蛋白质向线粒体的进口。这个项目的重点是易位成分如何识别、瞄准和转移它们的电荷;特别是,一类溶质载体的进口插入线粒体内膜。
英文摘要
All cellular proteins are made on ribosomes. Highly regulated transport systems then move them about the cell. Specialised 'translocases' mediate import of proteins to the mitochondria. This project focuses on how translocase components recognise, target, and transfer their charges; in particular, on the import of a class of solute carriers that insert into the inner mitochondrial membrane.
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会议论文
Investigating CRAC Channel Assembly and Interactions Important in Immunity
Dissecting the molecular basis of actin filament disassembly in the malaria parasite
Research Fellowship
Investigating the Interaction of Precursor Inner Membrane Proteins with Translocase Components
海外基金