SIMULATION OF MACROMOLECULAR TRANSPORT IN THE WALL OF BRANCHED ARTERIES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 保留字： 转运，血清白蛋白，脂蛋白，大分子 摘要： 动脉血流动力学和致动脉粥样硬化血浆成分（如低密度脂蛋白（LDL））的运输影响动脉粥样硬化的发生。在动脉树的分支和弯曲处的流动扰动和相关的壁剪切应力的改变是已知的控制动脉粥样硬化的现象。这些部位致动脉粥样硬化血浆成分的局部质量转移升高也是导致斑块形成的另一个因素。在这项研究中，模拟动脉血流动力学和动脉粥样硬化成分在三维T形接头瞬态流动条件下的传输进行。在数学模型中，采用广义动量平衡方程来模拟血液流动，采用对流扩散方程来模拟质量传递。在求解过程中，计算流体动力学（CFD）软件FLUENT 6.1将用于实施有限体积法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Keywords: transport, serum albumin, lipoprotein, macromolecules Abstract: Arterial blood flow dynamics and transport of atherogenic plasma components such as low-density lipoprotein (LDL) influence the genesis of athereosclerosis. Flow disturbances and the associated alteration of wall shear stress at branches and curvatures of the arterial tree are phenomenon known to control atherosclerosis. Elevated local mass transfer of atherogenic plasma components at those sites is also an additional factor which causes the build of plaque. In this study simulation of aterial blood flow dynamics and transport of atherogenic components in a three dimensional T-junction under transient flow conditions is carried out. The generalized momentum balance equation to model the blood flow and the advective-diffusion equation to model the mass transfer are used in the mathematical model. In the solution process Computational Flow Dynamics (CFD) Software FLUENT 6.1 will be used to implement the Finite volume method.