CONTRIBUTIONS OF PERIPHERAL / CENTRAL AIRWAYS TO AIRFLOW OBSTRUCTION IN ASTHMA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 哮喘是一种慢性疾病，困扰着全球数百万人。与哮喘相关的发病率和死亡率在过去20年中有所增加。哮喘最令人衰弱和最经典的特征之一是呼吸道高反应性，其原因是过度的气道狭窄和伴随的气流阻塞。为了更好地了解人类呼吸道高反应性的潜在机制，在疾病的动物模型中确定外周和中央气道对气流阻塞的各自贡献是重要的。目前，通过测量全肺阻力和/或顺应性来评估气道反应性。因此，没有直接的技术可以用来确定外周与中央气道的阻力或顺应性的变化。 这些成像研究将量化外周气道对哮喘小鼠模型气流阻塞的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Asthma is a chronic disease afflicting millions of people worldwide. The morbidity and mortality assocaited with asthma have increased over the past two decades. One of the most debilitating and classic features of asthma, airway hyperresponsiveness, results from excessive airway narrowing and concomitant airflow obstruction. To better understand the mechanisms underlying airway hyperresponsiveness in humans it is important to determine the respective contributions of peripheral and central airways to airflow obstruction in animal models of the disease. Currently, airway responsiveness is assessed by measuring whole lung resistance and/or compliance. Thus, there is no direct technique by which changes in resistance or compliance of peripheral vs central airways can be determined. These imaging studies would quantitate the contribution of peripheral airways to airflow obstruction in a mouse model of asthma.