CONTRIBUTIONS OF PERIPHERAL AND CENTRAL AIRWAYS TO AIRFLOW OBSTRUCTION IN ANIMA

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。哮喘是一种慢性疾病，困扰着全球数百万人。与哮喘相关的发病率和死亡率在过去20年中有所增加。哮喘最令人衰弱和最经典的特征之一是呼吸道高反应性，其原因是过度的气道狭窄和伴随的气流阻塞。为了更好地了解人类呼吸道高反应性的潜在机制，在疾病的动物模型中确定外周和中央气道对气流阻塞的各自贡献是重要的。目前，通过测量全肺阻力和/或顺应性来评估气道反应性。因此，没有直接的技术可以用来确定外周与中央气道的阻力或顺应性的变化。这些成像研究将量化外周气道对哮喘小鼠模型气流阻塞的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Asthma is a chronic disease afflicting millions of people worldwide. The morbidity and mortality assocaited with asthma have increased over the past two decades. One of the most debilitating and classic features of asthma, airway hyperresponsiveness, results from excessive airway narrowing and concomitant airflow obstruction. To better understand the mechanisms underlying airway hyperresponsiveness in humans it is important to determine the respective contributions of peripheral and central airways to airflow obstruction in animal models of the disease. Currently, airway responsiveness is assessed by measuring whole lung resistance and/or compliance. Thus, there is no direct technique by which changes in resistance or compliance of peripheral vs central airways can be determined. These imaging studies would quantitate the contribution of peripheral airways to airflow obstruction in a mouse model of asthma.