NIR ENZYME-ACTIVATED FLUOROGENIC PHOSPHOLIPIDS FOR MULTI-MODALITY IMAGING

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们正在分析化疗药物对前列腺癌细胞的影响，通过双模态的方法。使用核磁共振（NMR）光谱与近红外（NIR）荧光分子探针的组合，我们靶向磷脂酶功能，目的是描绘体内特定的细胞信号传导途径。 从分子成像方法中获得的信息可能会导致早期诊断和改善疾病的管理。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are analyzing the effects of chemotherapeutic drugs on prostate cancer cells via a dual-modality approach. Using a combination of Nuclear Magnetic Resonance (NMR) spectroscopy with near-infrared (NIR) fluorescent molecular probes we are targeting phospholipase function with the goal of delineating specific cell signaling pathways in vivo. The information gained from a molecular imaging approach may lead to earlier diagnoses and improved management of disease.