NEW TECHNIQUE FOR DYNAMIC CONTRAST ENHANCED BREAST MRI

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 动态对比MRI正广泛应用于肿瘤成像研究。 应用包括表征病变为良性或恶性和评估治疗反应。 人们特别感兴趣的是使用动态对比增强（DCE）MRI来早期检测靶向人类受试者和动物模型中血管生成的反应疗法。 以前，我们已经开发了一种交错的反投影成像技术，允许采集一系列的图像具有高的时间和空间分辨率（动态KWIC）。 最近，我们通过创建代表对比度增强动力学模型的各种参数的彩色图来增强病变的可视化和诊断。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dynamic contrast MRI is being widely applied to studies of cancer imaging. Applications include characterization of lesions as benign or malignant and assessing therpeutic response. There is particular interest in the use of dynamic contrast enhanced (DCE) MRI for the early detection of response therapies that target angiogenesis in human subjects and animal models. Previously we had developed an interleaved backprojection imaging technique that allows acquisition of a series of images with both high temporal and spatial resolutions (dynamic KWIC). More recently we have enhanced lesion visualization and diagnosis by creating color maps that represent various parameters of the contrast-enhancement kinetic model.