METABOLIC CORRELATES OF FUNCTIONAL MRI

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 功能磁共振研究依赖于脑血流量(CBF)的变化作为新陈代谢和神经活动变化的替代测量。在各种病理状态下，甚至在某些生理状态下，这些参数之间可能存在解偶联。该项目将开发和测试一种独特的多模式成像技术，将18F-氟代脱氧葡萄糖(FDG)注射过程中的功能磁共振成像(FMRI)与随后的FDG正电子发射断层扫描(FDG-PET)相结合，以同时测量脑血流和葡萄糖代谢。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Functional MRI studies rely on changes in cerebral blood flow (CBF) as a surrogate measure of changes in metabolism and neural activity. In various pathological states and possibly even in some physiological states, there may be an uncoupling between these parameters. This project will develop and test a unique multimodal imagaing technique combining functional magnetic resonance imaging (fMRI) during 18F-fluorodeoxyglucose (FDG) infusion and subsequent FDG positron emission tomography (FDG-PET) to measure cerebral blood flow and glucose metabolism concurrently.