DYNAMIC HELIUM-3 MRI OF THE REGIONAL SINUSES IN AN ANIMAL MODEL

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 慢性鼻窦炎影响着3300多万美国人。这个子项目的目标是开发一种评估鼻窦充气的技术。这可能会导致临床上最早的窦房结功能测量之一，可以用来指导窦房结治疗。为此，我们现在正在开发一种超极化MRI方法，用于测量鼻腔和副鼻窦内吸入气体的速度场。这使我们能够直接将实验测量数据与计算流体动力学方法预测的数据进行比较。我们最近在宾夕法尼亚大学的临床核磁共振系统上实施了这项技术，并正在对合适的鼻腔和鼻窦幻影进行测试。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chronic rhinosinusitis affects over 33 million Americans. The goal of this subproject is to develop a technique for assessing sinus aeration. This may lead to one of the first clinically measures of sinus function which may be used to guide sinus management. To this end we are now in the process of developing a hyperpolarized MRI method for measuring the velocity field of inhaled gases within the nasal cavity and paranasal sinuses. This allows us to directly compare experimentally measured data with those predicted by computation fluid dynamic methods. We have recently implemented this technique on a clinical MRI system at the University of Pennsylvania and are in the process of testing this on suitable nasal and sinus phantoms.