T-BOX CARDIAC PHENOTYPE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 T-box(Tbx)转录因子在不同物种中高度保守，在多种组织类型中表达，是不同器官和组织发育所必需的。T-box基因调控模式和细胞命运、细胞存活和/或增殖，也具有重要的临床意义。TBX18是一种T-box转录因子，已被描述为在心包前器官的早期表达。为了研究TBX18在心脏发育中的作用及其与人类先天性心脏病的临床相关性，我培育了一个TBX18的零等位基因小鼠。我们想通过与野生型小鼠的比较，对TBX18基因缺失小鼠进行一些透射电子显微镜分析，以确定它们的心脏缺陷。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. T-box (Tbx) transcription factors are highly conserved across species, expressed in a wide variety of tissue types, and are required for development of diverse organs and tissues. T-box genes regulate patterning and cell fate, cell survival and/or proliferation, and are also of great clinical relevance. Tbx18 is a T-box transcription factor that has been described as being expressed from earliest stages in the proepicardial organ. To study the role of Tbx18 for heart development and its clinical relevance for human congenital heart disease, I have generated a null allele mouse of Tbx18. We would like to do some TEM analysis to determine cardiac defects of Tbx18 null mouse, by comparing them with wild type littermates.