PREDICTING POTENTIAL OF VACCINE DEVELOPMENT AGAINST LEISHMANIA (L) MEXICANA PAR

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 二氢轮酸脱氢酶(DHODH)蛋白是一种 亚马逊利什曼原虫重要毒力因子。因为这件事 跨膜表面蛋白介导寄生虫对细胞的黏附 巨噬细胞，重要的是要研究这种分子在感染发生的早期事件中的作用，以及它被 用作这种寄生虫疫苗的候选者。这个基因和它的 在毒力方面的作用更早是来自马宗利什曼原虫(L) 新世界。这一信息不是利什曼原虫(L)墨西哥的已知信息 它是德克萨斯州南部皮肤利什曼病的病原体， 墨西哥、中美洲和南美洲。使用生物信息学工具 和技术我们想要对DHODH进行比较研究 墨西哥L.(L)2个品系，马宗氏L.(L)和L.(L)之间 墨西哥香槟。此外，我们还将预测它在疫苗方面的潜力 抗墨西哥血吸虫L.(L)感染

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Dihydroorotate dehydrogenase (DHODH) protein has been known to be an important virulent factor on Leishmania amazonensis. Because this transmembrane surface protein mediates adherence of the parasite to the macrophages, it is important to investigate the role of this molecule in the early events of the onset of infection, and also its potential to be used as a candidate for vaccine against this parasite. This gene and its role in virulence have earlier been from Leishmania (L) mazonensis in the New World. This information is not known from Leishmania (L) mexicana which is causal agent of Cutaneous leishmaniasis in southern Texas, Mexico, Central and South America. With the use of bioinformatics tools and techniques we would like to do comparative studies on DHODH for the two strains of L. (L) mexicana; and between L.(L) mazonensis and L.(L) mexicana. In addition we will also predict its potential for vaccine against L.(L) mexicana infection