MECHANISM OF ACTION OF THE BOTULISM TOXIN
MECHANISM OF ACTION OF THE BOTULISM TOXIN
批准号:
7601727
负责人:
Kim Janda
金额:
$0.18万
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-05-01 至 2008-04-30
中文摘要
这个子项目是许多研究子项目中利用
资源由NIH/NCRR资助的中心拨款提供。子项目和
调查员(PI)可能从NIH的另一个来源获得了主要资金,
并因此可以在其他清晰的条目中表示。列出的机构是
该中心不一定是调查人员的机构。
这是一个新的项目,目的是改进抑制肉毒杆菌毒素作用的试剂。AutoDock正被用于增强药物铅,方法是将已知的抑制剂扩展到毒素结合部位周围的区域。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
This is a new project to improve agents that act to inhibit the action of botulism toxin. AutoDock is being used for drug lead enhancement, by extending known inhibitors into areas around the binding site of the toxin.
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会议论文
An Enzyme-Based Antidote for Acute Nicotine Toxicity
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批准号:10790758
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项目类别:
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资助金额:$27.15万
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财政年份:2023
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负责人:Kim Janda
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依托单位:
Discovering modulators of exonucleases PLD3 and PLD4 for immunoregulation
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批准号:10620110
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项目类别:
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资助金额:$22.19万
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财政年份:2022
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负责人:Kim Janda
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依托单位:
Discovering modulators of exonucleases PLD3 and PLD4 for immunoregulation
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批准号:10353980
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项目类别:
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资助金额:$26.63万
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财政年份:2022
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负责人:Kim Janda
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依托单位:
High-Throughput Screen for the Oncoprotein MYC
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批准号:10276232
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项目类别:
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资助金额:$43.29万
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财政年份:2021
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负责人:Kim Janda
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依托单位:
High-Throughput Screen for the Oncoprotein MYC
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批准号:10657663
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项目类别:
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资助金额:$40.58万
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财政年份:2021
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负责人:Kim Janda
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依托单位:
High-Throughput Screen for the Oncoprotein MYC
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批准号:10436377
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项目类别:
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资助金额:$40.04万
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财政年份:2021
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负责人:Kim Janda
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依托单位:
Covalent Inhibition as a Method to Counteract Botulinum Intoxication
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批准号:10177867
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项目类别:
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资助金额:$63.79万
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财政年份:2020
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负责人:Kim Janda
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依托单位:
Covalent Inhibition as a Method to Counteract Botulinum Intoxication
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批准号:10408004
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项目类别:
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资助金额:$63.46万
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财政年份:2020
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负责人:Kim Janda
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依托单位:
Covalent Inhibition as a Method to Counteract Botulinum Intoxication
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批准号:10034607
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项目类别:
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资助金额:$69.27万
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财政年份:2020
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负责人:Kim Janda
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依托单位:
Covalent Inhibition as a Method to Counteract Botulinum Intoxication
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批准号:10624958
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项目类别:
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资助金额:$63.34万
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财政年份:2020
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负责人:Kim Janda
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依托单位:
"PRODUCTION AND DISTRIBUTION OF INVESTIGATIONAL GHRELIN VACCINES-- GHRELIN VACCINES AGAINST RAT HORMONE". TASK ORDER 5. 09/21/2019-12/31/2020.
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批准号:10037792
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项目类别:
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资助金额:$11.62万
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财政年份:2019
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负责人:Kim Janda
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依托单位:
Immunotherapy to Counteract Lethal Doses of Carfentanil
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批准号:9563769
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项目类别:
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资助金额:$52.07万
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财政年份:2019
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负责人:Kim Janda
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依托单位:
IGF::OT::IGF:The Scripps Research Institute. Task Order 3 (HHSN275201500006I/HHSN27500003)."Production and Distribution of Investigational Ghrelin Vaccines--Ghrelin Vaccine Against Rat Hormone. 09/21/
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批准号:9581309
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项目类别:
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资助金额:$12.24万
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财政年份:2017
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负责人:Kim Janda
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依托单位:
Enzympharmacotherapy for attenuating nicotine's psychoactive effects
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批准号:9342807
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项目类别:
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资助金额:$24.06万
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财政年份:2016
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负责人:Kim Janda
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依托单位:
A Multidisciplinary Approach for the Treatment of Botulinum Intoxication
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批准号:9313771
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项目类别:
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资助金额:$56.62万
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财政年份:2016
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负责人:Kim Janda
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依托单位:
IGF::OT::IGF:THE SCRIPPS RESEARCH INSTITUTE. TASK ORDER 2 (HHSN275201500006I/HHSN27500002)."PRODUCTION AND DISTRIBUTION OF INVESTIGATIONAL GHRELIN VACCINES--GHRELIN VACCINE AGAINST RAT HORMONE. 09/21/
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批准号:9361316
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项目类别:
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资助金额:$9.4万
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财政年份:2016
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负责人:Kim Janda
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依托单位:
A Multidisciplinary Approach for the Treatment of Botulinum Intoxication
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批准号:9179027
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项目类别:
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资助金额:$62.82万
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财政年份:2016
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负责人:Kim Janda
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依托单位:
IGF::OT::IGF:THE SCRIPPS RESEARCH INSTITUTE. TASK ORDER 2 (HHSN275201500006I/HHSN27500002)."PRODUCTION AND DISTRIBUTION OF INVESTIGATIONAL GHRELIN VACCINES--GHRELIN VACCINE AGAINST RAT HORMONE. 09/21/
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批准号:9521688
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项目类别:
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资助金额:$2.43万
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财政年份:2016
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负责人:Kim Janda
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依托单位:
Using Allosteric Inhibition as a Means to Ablate Botulinum Neurotoxin Protease
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批准号:9197258
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项目类别:
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资助金额:$24.06万
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财政年份:2015
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负责人:Kim Janda
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依托单位:
Approaches to Counteract the Harmful Effects of Synthetic Opioid Designer Drugs
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批准号:8912027
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项目类别:
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资助金额:$28.43万
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财政年份:2015
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负责人:Kim Janda
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依托单位:
海外基金