REGIONAL MYOCARDIAL PERFUSION & MECH USING 3D MYOCARDIAL CONTRAST ECHOCARDIO

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是： a.将灌注心肌的均匀化描述应用到心脏有限元模型中，并利用三维超声成像验证该模型。 B.使用非线性横观各向同性材料描述开发二尖瓣的有限元模型，并使用3-D变形数据对其进行验证 C.研究左心室辅助装置对自体心脏和心血管系统的流体力学相互作用。 我们目前正在使用Continuity进行心脏和瓣膜的固体力学建模，特别是将我们自己的材料描述集成到软件中的能力。一个新项目（c）专注于流体力学，因此将Continuity的解决方案与我们的CFD软件耦合或接口的能力将使该领域非常感兴趣的固体-流体相互作用的研究成为可能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Aims of this research are: a. To implement a homogenization description of perfused myocardium into a finite element model of the heart, and validate this model using 3-D ultrasound imaging. b. To develop a finite element model of the mitral valve using a nonlinear transversely isotropic material description, and validate it using 3-D deformation data c. To study the fluid mechanics interaction of the native heart and cardiovascular system with left ventricular assist devices. We are presently using Continuity for solid mechanics modeling of the heart and valve, particularly the ability to integrate our own material descriptions into the software. A new project (c) is focused on fluid mechanics, so the ability to couple or interface solutions from Continuity with our CFD software would enable the study of solid-fluid interactions which are of great interest in this area.