REAL TIME FMRI AUGMENTED LEARNED CONTROL OF BRAIN ACTIVATION AND PAIN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 导言： 如果一个人能够学会直接控制大脑中局部区域的激活，这种方法可能会提供对调节行为和认知的神经生理机制的控制，并可能提供一种不同的治疗疾病的途径。控制内源性疼痛调节系统是一个特别重要的目标，因为它可以为临床控制疼痛提供一种独特的机制。 方法和讨论： 来自斯坦福大学疼痛管理中心的10名(2男：8女)慢性疼痛患者接受了使用认知策略增加和减少rACC目标ROI中脑激活的训练。在每次13分钟的跑步后，患者对增加期间与减少情况下疼痛强度的差异进行量化评级。受试者接受2-3次/次的训练，共6次。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: If an individual can learn to directly control activation of localized regions within the brain, this approach might provide control over the neurophysiological mechanisms that mediate behavior and cognition and could potentially provide a different route for treating disease. Control over the endogenous pain modulatory system is a particularly important target because it could enable a unique mechanism for clinical control over pain. Methods and Discussion: 10 (2 M: 8 F) chronic pain patients from the Stanford University Pain Management Center were trained to increase and then to decrease brain activation in the rACC target ROI using cognitive strategies. Following each 13-min run, patients made quantitative ratings of the difference in pain intensity during the increase compared to the decrease conditions. atients received 2-3 training runs/session for 6 sessions.