WHITE MATTER ARCHITECTURE FROM DIFFUSION MRI

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 White Matter架构核心的首要目标是追求技术 提高对脑白质解剖学理解的进展。是这样的 了解，特别是由于神经通路相对于当前成像分辨率的小尺寸，对于开发分析解剖结构的新方法和技术以及将这些分析应用于了解神经疾病至关重要。这些信息自然是对从标准结构分析中获得的地图集信息的补充。 临床目的是检测和定位脑白质异常。 使用扩散磁共振成像和后处理成像技术的精神分裂症，尽管我们 预计所开发的方法将适用于广泛的白质 疾病。为了解决白质结构和异常的问题，我们有 开发了一种分析白质的新技术，以及用于可视化和交互探索3D扩散MRI数据的工具。除了支持这一核心的特定需求外，这些工具还被直接应用于早期检测发育中的婴儿大脑中的白质损害；探索和描述多发性硬化症损害造成的白质破坏；以及神经外科手术期间重要的白质纤维束的可视化(例如，连接运动皮质和脊髓下部运动中心的皮质脊髓束)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overarching goal of the White Matter Architecture core is to pursue technological developments that improve the understanding of white matter anatomy. Such understanding, particularly owing to the small dimension of the neural pathways relative to current imaging resolution, is vital to developing novel methods and techniques for the analysis of anatomical structures, and for the application of those analyses to understanding neural diseases. This information naturally complements atlas information obtained from standard structural analysis. The clinical objective is to detect and localize white matter brain abnormalities in schizophrenia using techniques in diffusion MRI and post-process imaging, although we expect that the methods developed will be applicable to a broad range of white matter disease. To address the issue of white matter structure and abnormalities, we have developed a new technology for analyzing white matter along with tools for visualization and interactive exploration of 3D diffusion MRI data. In addition to supporting the specific needs of this core, these tools have been applied directly to the early detection of white matter damage in the developing infant brain; exploration and characterization of white matter disruptions caused by MS lesions; and visualization of important white matter fiber tracts during neurosurgical procedures (e.g., the cortical spinal tract connecting the motor cortex with the lower motor centers of the spinal cord.)