PROTEOMICS CORE

2.a.2.总体目标 蛋白质组学核心旨在为MRDDRC研究人员提供最先进的技术， 质谱和微量毛细管高效液相色谱（蛋白质组学）， 神经发育障碍的细胞和分子生物学的高级研究。格林伯格博士 (the该委员会主任将担任核心主任。Jebanathirajah博士，一位新的助理教授 在儿童医院的神经生物学项目，在质谱领域的专家，将是 负责监督所有核心活动的经理。核心的主要目标是使用这些技术 质谱分析，以协助MRDDRC研究人员在蛋白质复合物的表征， 与神经元功能相关，以表征神经系统中发生的蛋白质组成变化 在发展过程中和导致发展障碍的条件下，并确定和 表征神经元蛋白的翻译后修饰的功能。蛋白质组学核心是 积极参与质谱领域的研究，任何新开发的工具和方法都将 向MRDDRC调查人员提供。核心还将提供和开发与蛋白质组学相关的 统计和数据处理工具。

2.a.2. Overall Objective The Proteomics Core aims to provide MRDDRC investigators with access to state of the art technologies in mass spectrometry and microscale capillary high performance liquid chromatography (proteomics) required for advanced studies in the cell and molecular biology of neurological developmental disabilities. Dr Greenberg (the Director of this MRDDRC) will be the Director of the Core. Dr. Jebanathirajah, a new Assistant Professor in the Neurobiology Program at Children's Hospital, and an expert in the field of mass spectrometry, will be the Manager responsible for supervising all Core activities. Major goals of the Core will be to use the techniques of mass spectrometry to assist MRDDRC investigators in the characterization of protein complexes that are relevant to neuronal function, to characterize changes in protein composition that occur in the nervous system during development and under conditions that lead to developmental disabilities, and to identify and characterize the function of post-translational modification of neuronal proteins. The Proteomics Core is actively involved in research in the area of mass spectrometry and any newly developed tools and methods will be made available to the MRDDRC investigators. The Core will also provide and develop proteomics related statistical and data handling tools.